Human Gene Set: CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_DN


Standard name CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_DN
Systematic name M7910
Brief description Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112].
Full description or abstract To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12704389   Authors: Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE
Exact source Table 2S: HDMP DC < 0 & HDMP p val. < 0.01
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 AFFY_HG_U95
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Version history 3.0: First introduced

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