Human Gene Set: CARRILLOREIXACH_MRS3_VS_LOWER_RISK_HEPATOBLASTOMA_DN


Standard name CARRILLOREIXACH_MRS3_VS_LOWER_RISK_HEPATOBLASTOMA_DN
Systematic name M45039
Brief description Genes significantly down-regulated in the high-risk Molecular Risk Stratification (MRS-3) hepatoblastoma (HB) as compared with intermediate-risk (MRS-2) and low-risk (MRS-1) molecular HBs, assessed by Human Transcriptome Array (HTA).
Full description or abstract Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32240714   Authors: Carrillo-Reixach J,Torrens L,Simon-Coma M,Royo L,Domingo-Sàbat M,Abril-Fornaguera J,Akers N,Sala M,Ragull S,Arnal M,Villalmanzo N,Cairo S,Villanueva A,Kappler R,Garrido M,Guerra L,Sábado C,Guillén G,Mallo M,Piñeyro D,Vázquez-Vitali M,Kuchuk O,Mateos ME,Ramírez G,Santamaría ML,Mozo Y,Soriano A,Grotzer M,Branchereau S,de Andoin NG,López-Ibor B,López-Almaraz R,Salinas JA,Torres B,Hernández F,Uriz JJ,Fabre M,Blanco J,Paris C,Baj?iová V,Laureys G,Masnou H,Clos A,Belendez C,Guettier C,Sumoy L,Planas R,Jordà M,Nonell L,Czauderna P,Morland B,Sia D,Losic B,Buendia MA,Sarrias MR,Llovet JM,Armengol C
Exact source Supplementary Table 9; F-Test p<0.00001, FC MRS3vsMRS1<=-2 & FC MRS3vsMRS2<=-2
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External links https://www.sciencedirect.com/science/article/pii/S0168827820301872?via%3Dihub
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Source species Homo sapiens
Contributed by Carolina Armengol (Germans Trias i Pujol Research Institute (IGTP))
Source platform or
identifier namespace		 AFFY_HTA_2.0
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Version history 2022.1.Hs: First Introduced.

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