Human Gene Set: CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_HYPOMETHYLATED_AND_UP


Standard name CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_HYPOMETHYLATED_AND_UP
Systematic name M45037
Brief description Genes hypomethylated and overexpressed in hepatoblastoma (HB) tumors as compared with non-tumor (NT) adjacent tissue assessed by Infinium MethylationEPIC 850K array and Human Transcriptome Array 2.0 & RNA-sequencing.
Full description or abstract Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32240714   Authors: Carrillo-Reixach J,Torrens L,Simon-Coma M,Royo L,Domingo-Sàbat M,Abril-Fornaguera J,Akers N,Sala M,Ragull S,Arnal M,Villalmanzo N,Cairo S,Villanueva A,Kappler R,Garrido M,Guerra L,Sábado C,Guillén G,Mallo M,Piñeyro D,Vázquez-Vitali M,Kuchuk O,Mateos ME,Ramírez G,Santamaría ML,Mozo Y,Soriano A,Grotzer M,Branchereau S,de Andoin NG,López-Ibor B,López-Almaraz R,Salinas JA,Torres B,Hernández F,Uriz JJ,Fabre M,Blanco J,Paris C,Baj?iová V,Laureys G,Masnou H,Clos A,Belendez C,Guettier C,Sumoy L,Planas R,Jordà M,Nonell L,Czauderna P,Morland B,Sia D,Losic B,Buendia MA,Sarrias MR,Llovet JM,Armengol C
Exact source Supplementary Table 6; Methylation array:FDR p<0.0001 and __<-0.20; HTA 2.0: FDR p<0.05 and FC>=2; RNAseq: FDR p<0.05 and FC>=2
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External links https://www.sciencedirect.com/science/article/pii/S0168827820301872?via%3Dihub
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Source species Homo sapiens
Contributed by Carolina Armengol (Germans Trias i Pujol Research Institute (IGTP))
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identifier namespace		 Human_Ensembl_Gene_ID
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Version history 2022.1.Hs: First Introduced.

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