Human Gene Set: BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS

For the Mouse gene set with the same name, see BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS

Standard name BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS
Systematic name M2388
Brief description Transcripts in hematopoietic stem cells (HSC) which are trans-regulated (i.e., modulated by a QTL (quantitative trait locus) not in a close proximity to the gene).
Full description or abstract We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts. By comparing the physical transcript position with the location of the controlling QTL, we identified polymorphic cis-acting stem cell genes. We also identified multiple trans-acting control loci that modify expression of large numbers of genes. These groups of coregulated transcripts identify pathways that specify variation in stem cells. We illustrate this concept with the identification of candidate genes involved with HSC turnover. We compared expression QTLs in HSCs and brain from the same mice and identified both shared and tissue-specific QTLs. Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15711547   Authors: Bystrykh L,Weersing E,Dontje B,Sutton S,Pletcher MT,Wiltshire T,Su AI,Vellenga E,Wang J,Manly KF,Lu L,Chesler EJ,Alberts R,Jansen RC,Williams RW,Cooke MP,de Haan G
Exact source Table 3S
Related gene sets (show 9 additional gene sets from the source publication)

(show 37 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jean Junior (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 786 genes
Gene families ? Categorize these 786 genes by gene family
Show members (show 1057 source identifiers mapped to 786 genes)
Version history 3.0: Renamed from BYSTRYKH_HSC_TRANS_REGULATED_QTL

See MSigDB license terms here. Please note that certain gene sets have special access terms.