Human Gene Set: BROWNE_INTERFERON_RESPONSIVE_GENES


Standard name BROWNE_INTERFERON_RESPONSIVE_GENES
Systematic name M9221
Brief description Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h.
Full description or abstract The effect of human cytomegalovirus (HCMV) infection on cellular mRNA accumulation was analyzed by gene chip technology. During a 48-h time course after infection of human diploid fibroblasts, 1,425 cellular mRNAs were found to be up-regulated or down-regulated by threefold or greater in at least two consecutive time points. Several classes of genes were prominently affected, including interferon response genes, cell cycle regulators, apoptosis regulators, inflammatory pathway genes, and immune regulators. The number of mRNAs that were up-regulated or down-regulated were roughly equal over the complete time course. However, for the first 8 h after infection, the number of up-regulated mRNAs was significantly less than the number of down-regulated mRNAs. By analyzing the mRNA expression profile of cells infected in the presence of cycloheximide, it was found that a minimum of 25 mRNAs were modulated by HCMV in the absence of protein synthesis. These included mRNAs encoded by a small number of interferon-responsive genes, as well as beta interferon itself. Cellular mRNA levels in cytomegalovirus-infected cells were compared to the levels in cells infected with UV-inactivated virus. The inactivated virus caused the up-regulation of a much greater number of mRNAs, many of which encoded proteins with antiviral roles, such as interferon-responsive genes and proinflammatory cytokines. These data argue that one or more newly synthesized viral gene products block the induction of antiviral pathways that are triggered by HCMV binding and entry.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11711622   Authors: Browne EP,Wing B,Coleman D,Shenk T
Exact source Table 2S: intersection of genes up-regulated by IFN
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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identifier namespace		 AFFY_HG_U95
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Version history 3.0: Renamed from IFNA_HCMV_6HRS_UP

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