Human Gene Set: BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

For the Mouse gene set with the same name, see BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

Standard name BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP
Systematic name M15542
Brief description Genes up-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes are independent of ATM [GeneID=472] signaling.
Full description or abstract DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks includes the activation of transcriptional programs known primarily to regulate cell-cycle checkpoints and cell survival. DNA double-strand breaks are generated in all developing lymphocytes during the assembly of antigen receptor genes, a process that is essential for normal lymphocyte development. Here we show that in murine lymphocytes these physiological DNA breaks activate a broad transcriptional program. This program transcends the canonical DNA double-strand break response and includes many genes that regulate diverse cellular processes important for lymphocyte development. Moreover, the expression of several of these genes is regulated similarly in response to genotoxic DNA damage. Thus, physiological DNA double-strand breaks provide cues that can regulate cell-type-specific processes not directly involved in maintaining the integrity of the genome, and genotoxic DNA breaks could disrupt normal cellular functions by corrupting these processes.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18849970   Authors: Bredemeyer AL,Helmink BA,Innes CL,Calderon B,McGinnis LM,Mahowald GK,Gapud EJ,Walker LM,Collins JB,Weaver BK,Mandik-Nayak L,Schreiber RD,Allen PM,May MJ,Paules RS,Bassing CH,Sleckman BP
Exact source Table 1S
Related gene sets (show 3 additional gene sets from the source publication)

(show 12 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 65 genes
Gene families ? Categorize these 65 genes by gene family
Show members (show 102 source identifiers mapped to 65 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.