Human Gene Set: BOYLAN_MULTIPLE_MYELOMA_C_D_DN

For the Mouse gene set with the same name, see BOYLAN_MULTIPLE_MYELOMA_C_D_DN

Standard name BOYLAN_MULTIPLE_MYELOMA_C_D_DN
Systematic name M8646
Brief description Genes down-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.
Full description or abstract Multiple myeloma is an incurable plasma cell malignancy for which existing animal models are limited. We have previously shown that the targeted expression of the transgenes c-Myc and Bcl-X(L) in murine plasma cells produces malignancy that displays features of human myeloma, such as localization of tumor cells to the bone marrow and lytic bone lesions. We have isolated and characterized in vitro cultures and adoptive transfers of tumors from Bcl-xl/Myc transgenic mice. Tumors have a plasmablastic morphology and variable expression of CD138, CD45, CD38, and CD19. Spectral karyotyping analysis of metaphase chromosomes from primary tumor cell cultures shows that the Bcl-xl/Myc tumors contain a variety of chromosomal abnormalities, including trisomies, translocations, and deletions. The most frequently aberrant chromosomes are 12 and 16. Three sites for recurring translocations were also identified on chromosomes 4D, 12F, and 16C. Gene expression profiling was used to identify differences in gene expression between tumor cells and normal plasma cells (NPC) and to cluster the tumors into two groups (tumor groups C and D), with distinct gene expression profiles. Four hundred and ninety-five genes were significantly different between both tumor groups and NPCs, whereas 124 genes were uniquely different from NPCs in tumor group C and 204 genes were uniquely different from NPCs in tumor group D. Similar to human myeloma, the cyclin D genes are differentially dysregulated in the mouse tumor groups. These data suggest the Bcl-xl/Myc tumors are similar to a subset of plasmablastic human myelomas and provide insight into the specific genes and pathways underlying the human disease.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17483317   Authors: Boylan KL,Gosse MA,Staggs SE,Janz S,Grindle S,Kansas GS,Van Ness BG
Exact source Table 5S: Tumor Group=C and D & Fold Change < 0
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 AFFY_Mouse430
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Version history 3.0: First introduced

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