Human Gene Set: BIOCARTA_TCR_PATHWAY

For the Mouse gene set with the same name, see BIOCARTA_TCR_PATHWAY

Standard name BIOCARTA_TCR_PATHWAY
Systematic name M19784
Brief description T Cell Receptor Signaling Pathway
Full description or abstract The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains (shown here) or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinary upon engagement of the receptor.
Collection C2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
Source publication  
Exact source  
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_tcrPathway.gif
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Source species Homo sapiens
Contributed by BioCarta
Source platform or
identifier namespace		 HUMAN_SEQ_ACCESSION
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GTEx compendium
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NCI-60 cell lines (National Cancer Institute)

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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 44 genes
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Show members (show 115 source identifiers mapped to 44 genes)
Version history 7.0: Changed members. Upgraded to final version of Biocarta.


License Terms for BioCarta data in MSigDB

MSigDB gene sets derived from BioCarta pathways are protected by copyright, (c) 2000-2017 BioCarta, all rights reserved. They are provided under license to the Broad Institute, Inc. with qualified permission to include in this release, subject to Biocarta's "Disclaimer of Liability and of Warranties" (formerly found at www.biocarta.com). Inclusion of these gene sets is conditioned upon acknowledgment and retention of the aforementioned copyright, and agreement to such disclaimer. The BioCarta derived gene sets are in the MSigDB C2 and M2 collections, and can be recognized by the "BIOCARTA_" prefix in their name.

See the full MSigDB license terms here.