Human Gene Set: BIOCARTA_TCAPOPTOSIS_PATHWAY

For the Mouse gene set with the same name, see BIOCARTA_TCAPOPTOSIS_PATHWAY

Standard name BIOCARTA_TCAPOPTOSIS_PATHWAY
Systematic name M16519
Brief description HIV Induced T Cell Apoptosis
Full description or abstract HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction.
Collection C2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
Source publication  
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_tcapoptosisPathway.gif
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Source species Homo sapiens
Contributed by BioCarta
Source platform or
identifier namespace		 Human_RefSeq
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.


License Terms for BioCarta data in MSigDB

MSigDB gene sets derived from BioCarta pathways are protected by copyright, (c) 2000-2017 BioCarta, all rights reserved. They are provided under license to the Broad Institute, Inc. with qualified permission to include in this release, subject to Biocarta's "Disclaimer of Liability and of Warranties" (formerly found at www.biocarta.com). Inclusion of these gene sets is conditioned upon acknowledgment and retention of the aforementioned copyright, and agreement to such disclaimer. The BioCarta derived gene sets are in the MSigDB C2 and M2 collections, and can be recognized by the "BIOCARTA_" prefix in their name.

See the full MSigDB license terms here.