IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of IL-10 appear to require induction of the enzyme heme oxygenase-1 (HO-1) through a map kinase pathway involving the p38 kinases. HO-1 is involved in the biosynthesis of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress. Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of IL-10. The anti-inflammatory actions of HO-1 appear to be the result of signaling by carbon monoxide it produces since removal of CO blocks the anti-inflammatory action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically useful either directly or through modulation of HO-1 activity.
7.0: Changed members. Upgraded to final version of Biocarta.
License Terms for BioCarta data in MSigDB
MSigDB gene sets derived from BioCarta pathways are protected by copyright, (c) 2000-2017 BioCarta, all rights reserved. They are provided
under license to the Broad Institute, Inc. with qualified permission to include in this release, subject to Biocarta's
"Disclaimer
of Liability and of Warranties" (formerly found at www.biocarta.com). Inclusion of these gene
sets is conditioned upon acknowledgment and retention of the aforementioned copyright, and agreement to such disclaimer. The BioCarta
derived gene sets are in the MSigDB C2 and M2 collections, and can be recognized by the "BIOCARTA_" prefix in their name.
