Human Gene Set: BIOCARTA_CFTR_PATHWAY

For the Mouse gene set with the same name, see BIOCARTA_CFTR_PATHWAY

Standard name BIOCARTA_CFTR_PATHWAY
Systematic name M12399
Brief description Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway
Full description or abstract The defects in cAMP-regulated chloride channel CTFR are believed to be the major cause for cystic fibrosis. Regulation of CFTR protein by the surface receptor beta adrenergic receptor is mediated through the ezrin/radixin/moesin binding phosphoprotein 50 (EBP50), which binds both the C-termini CFTR and b2AR through their PDZ binding motifs. In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells. Upon agonist activation of the b2AR, the adenulate cyclase is stimulated through the G protein pathway, leading to an increase in cAMP. The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin. The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific signaling of the channel.
Collection C2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_cftrPathway.gif
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Source species Homo sapiens
Contributed by BioCarta
Source platform or
identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.


License Terms for BioCarta data in MSigDB

MSigDB gene sets derived from BioCarta pathways are protected by copyright, (c) 2000-2017 BioCarta, all rights reserved. They are provided under license to the Broad Institute, Inc. with qualified permission to include in this release, subject to Biocarta's "Disclaimer of Liability and of Warranties" (formerly found at www.biocarta.com). Inclusion of these gene sets is conditioned upon acknowledgment and retention of the aforementioned copyright, and agreement to such disclaimer. The BioCarta derived gene sets are in the MSigDB C2 and M2 collections, and can be recognized by the "BIOCARTA_" prefix in their name.

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