Human Gene Set: BIOCARTA_BLYMPHOCYTE_PATHWAY

For the Mouse gene set with the same name, see BIOCARTA_BLYMPHOCYTE_PATHWAY

Standard name BIOCARTA_BLYMPHOCYTE_PATHWAY
Systematic name M1473
Brief description B Lymphocyte Cell Surface Molecules
Full description or abstract B cells must communicate with their environment to participate in the immune system as the source of antigen-specific immunoglobulins. Cell surface proteins on B cells receive signals from the exterior, adhere to other cells, and transmit signals to other cells. Antigen recognized by a B cell's immunoglobulin is presented in MHC Class II to T cells during B cell activation. Cell surface immunoglobulins are a key to B cell function, assisting in the response of B cells to specific antigen recognized by that cell's immunoglobulin. CD54 (ICAM-1) is an adhesion molecule involved in the binding of B cells to other cell types and LFA-1 is an integrin adhesion protein with two subunits that binds to ICAM. CD35 and CD21 are receptors for complement factors that stimulate the B cell response when complement is activated. CD80 and CD40 bind to T cell proteins (CD28 and CD40L, respectively) to provide costimulatory signals in the B cell-T cell interaction required for B cell activation. CD45 is a protein tyrosine phosphatase that regulates activation of B cells and T cells through dephosphorylation of signaling factors. CD32 is a receptor for IgG Fc, and is also called FcgammaRII. The number of proteins on the surface of B cell proteins indicates the complexity of regulation of B cell activation.
Collection C2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_blymphocytePathway.gif
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Source species Homo sapiens
Contributed by BioCarta
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identifier namespace		 Human_RefSeq
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.

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