Human Gene Set: BILBAN_B_CLL_LPL_DN


Standard name BILBAN_B_CLL_LPL_DN
Systematic name M14940
Brief description Genes down-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [GeneID=4023] compared with those expressing low levels of the gene.
Full description or abstract Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-CLLs selected for either high ('LPL+', n=10) or low ('LPL-', n=10) LPL mRNA expression. Selected genes were verified by real-time PCR in an extended patient cohort (n=42). A total of 111 genes discriminated LPL+ from LPL- B-CLLs. Of these, the top three genes associated with time to first treatment were Septin10, DMD and Gravin (P
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16617321   Authors: Bilban M,Heintel D,Scharl T,Woelfel T,Auer MM,Porpaczy E,Kainz B,Kröber A,Carey VJ,Shehata M,Zielinski C,Pickl W,Stilgenbauer S,Gaiger A,Wagner O,Jäger U,German CLL Study Group
Exact source Table 1BS
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
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Version history 3.0: First introduced


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