Human Gene Set: AMIT_DELAYED_EARLY_GENES


Standard name AMIT_DELAYED_EARLY_GENES
Systematic name M10550
Brief description Delayed early genes (DEG) which are coordinately down-regulated in multiple epithelial tumor types.
Full description or abstract Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regulation of transcription and mRNA stability, we demonstrate that a number of genes within the delayed early gene cluster function as feedback regulators of immediate early genes. Consistent with their role in negative regulation of cell signaling, genes within this cluster are downregulated in diverse tumor types, in correlation with clinical outcome. More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17322878   Authors: Amit I,Citri A,Shay T,Lu Y,Katz M,Zhang F,Tarcic G,Siwak D,Lahad J,Jacob-Hirsch J,Amariglio N,Vaisman N,Segal E,Rechavi G,Alon U,Mills GB,Domany E,Yarden Y
Exact source Fig 5a
Related gene sets (show 18 additional gene sets from the source publication)

(show 638 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 3 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 18 genes
Gene families ? Categorize these 18 genes by gene family
Show members (show 18 source identifiers mapped to 18 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.