Human Gene Set: YU_MYC_TARGETS_DN

For the Mouse gene set with the same name, see YU_MYC_TARGETS_DN

Standard name YU_MYC_TARGETS_DN
Systematic name M3923
Brief description Genes down-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609].
Full description or abstract The involvement of the c-Myc transcription factor in neoplastic transformation is well documented. However, which of its numerous target genes are crucial for tumorigenesis remains a frequently contested issue. We have recently established a non-transgenic murine model for B-cell lymphoma based on neoplastic conversion of p53-null bone marrow cells by conditionally active Myc. Using this model, we have identified a number of genes whose expression levels are affected by Myc during B-lymphomagenesis. Here we discuss their possible roles in neoplastic processes and describe an experimental approach allowing in vivo validation of these roles. We demonstrate that lymphoma cells overexpressing one of the Myc targets, the interleukin-10 receptor gene, have a very strong selective advantage over low IL10R expressors. Furthermore, Mcl1, a presumptive IL10R effector, also confers selective advantages when overexpressed in Myc-transformed hematopoietic cells. Thus, both IL10R and Mcl1 might be amenable to therapeutic interventions, and new targets can be identified and validated using the selection approach.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16382050   Authors: Yu D,Cozma D,Park A,Thomas-Tikhonenko A
Exact source Table 2
Related gene sets (show 1 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 AFFY_MG_U74
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 60 genes
Gene families ? Categorize these 60 genes by gene family
Show members (show 68 source identifiers mapped to 60 genes)
Version history 3.0: Renamed from YU_CMYC_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.