Standard name |
YAMANAKA_GLIOBLASTOMA_SURVIVAL_DN |
Systematic name |
M1948 |
Brief description |
Genes whose expression most strongly and consistently associated with the short term survival of patients with high grade glioma tumors. |
Full description or abstract |
Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes coupled with a class prediction model could be used to define subgroups of high-grade gliomas in a more objective manner than standard pathology. RNAs from 29 malignant gliomas were analysed using Agilent microarrays. We identified 21 genes whose expression was most strongly and consistently related to patient survival based on univariate proportional hazards models. In six out of 10 genes, changes in gene expression were validated by quantitative real-time PCR. After adjusting for clinical covariates based on a multivariate analysis, we finally obtained a statistical significance level for DDR1 (discoidin domain receptor family, member 1), DYRK3 (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 3) and KSP37 (Ksp37 protein). In independent samples, it was confirmed that DDR1 protein expression was also correlated to the prognosis of glioma patients detected by immunohistochemical staining. Furthermore, we analysed the efficacy of the short interfering RNA (siRNA)-mediated inhibition of DDR1 mRNA synthesis in glioma cell lines. Cell proliferation and invasion were significantly suppressed by siRNA against DDR1. Thus, DDR1 can be a novel molecular target of therapy as well as an important predictive marker for survival in patients with glioma. Our method was effective at classifying high-grade gliomas objectively, and provided a more accurate predictor of prognosis than histological grading. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 16652150 Authors: Yamanaka R,Arao T,Yajima N,Tsuchiya N,Homma J,Tanaka R,Sano M,Oide A,Sekijima M,Nishio K |
Exact source |
Table 3: hazard ratio > 1 |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 9 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
HUMAN_SEQ_ACCESSION |
Dataset references |
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format: grp | gmt | xml | json | TSV metadata |
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 8 genes
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Gene families ? |
Categorize these
8 genes by gene family
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Show members |
(show 9 source identifiers mapped to 8 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AA404652 |
10379 |
IRF9 |
interferon regulatory factor 9 [Source:HG... |
AF231512 |
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AL137662 |
340371 |
NRBP2 |
nuclear receptor binding protein 2 [Sourc... |
BAB22510 |
219854 |
TMEM218 |
transmembrane protein 218 [Source:HGNC Sy... |
BC005861 |
3689 |
ITGB2 |
integrin subunit beta 2 [Source:HGNC Symb... |
BE045190 |
780 |
DDR1 |
discoidin domain receptor tyrosine kinase... |
N92498 |
27250 |
PDCD4 |
programmed cell death 4 [Source:HGNC Symb... |
U20362 |
8100 |
IFT88 |
intraflagellar transport 88 [Source:HGNC ... |
Y10183 |
214 |
ALCAM |
activated leukocyte cell adhesion molecul... |
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Version history |
3.1: First introduced
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