Human Gene Set: UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_MONOCYTE_DN


Standard name UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_MONOCYTE_DN
Systematic name M48292
Brief description Genes downregulated in Monocytes from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors
Full description or abstract Thirty-eight PBMC samples from 25 patients with IPF and 13 matched controls yielded 149,564 cells that segregated into 23 subpopulations. Classical monocytes were increased in progressive and stable IPF compared to controls (32.1%, 25.2%, 17.9%, respectively, p<0.05). Total lymphocytes were decreased in IPF vs controls, and in progressive vs stable IPF (52.6% vs 62.6%, p=0.035). Tregs were increased in progressive vs stable IPF (1.8% vs 1.1% of all PBMC, p=0.007), although not different than controls, and may be associated with decreased survival (P=0.009 in Kaplan-Meier analysis; P=0.069 after adjusting for age, sex, and baseline FVC). Flow cytometry analysis confirmed this finding in an independent cohort of IPF patients. Fraction of Tregs out of all T cells was also increased in two cohorts of lung scRNA-seq. CCL22 and CCL18, ligands for CCR4 and CCR8 Treg chemotaxis receptors, were increased in IPF. The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs). (From Abstract)
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38717443   Authors: Unterman A,Zhao AY,Neumark N,Schupp JC,Ahangari F,Cosme C Jr,Sharma P,Flint J,Stein Y,Ryu C,Ishikawa G,Sumida TS,Gomez JL,Herazo-Maya JD,Dela Cruz CS,Herzog EL,Kaminski N
Exact source table_e5_degs_progressivevsstable2, avg_LogFC<0, p_val_adg<0.05
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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