Human Gene Set: TSENG_ADIPOGENIC_POTENTIAL_DN

For the Mouse gene set with the same name, see TSENG_ADIPOGENIC_POTENTIAL_DN

Standard name TSENG_ADIPOGENIC_POTENTIAL_DN
Systematic name M8364
Brief description Genes showing decreasing expression in brown preadipocytes with increasing ability of the cells to differentiate.
Full description or abstract The insulin/IGF-1 (insulin-like growth factor 1) signalling pathway promotes adipocyte differentiation via complex signalling networks. Here, using microarray analysis of brown preadipocytes that are derived from wild-type and insulin receptor substrate (Irs) knockout animals that exhibit progressively impaired differentiation, we define 374 genes/expressed-sequence tags whose expression in preadipocytes correlates with the ultimate ability of the cells to differentiate. Many of these genes, including preadipocyte factor-1 (Pref-1) and multiple members of the Wnt signalling pathway, are related to early adipogenic events. Necdin is also markedly increased in Irs knockout cells that cannot differentiate, and knockdown of necdin restores brown adipogenesis with downregulation of Pref-1 and Wnt10a expression. Insulin receptor substrate proteins regulate a necdin-E2F4 interaction that represses peroxisome-proliferator-activated receptor gamma (PPARgamma) transcription via a cyclic AMP response element binding protein (CREB)-dependent pathway. Together these define a key signalling network that is involved in brown preadipocyte determination.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15895078   Authors: Tseng YH,Butte AJ,Kokkotou E,Yechoor VK,Taniguchi CM,Kriauciunas KM,Cypess AM,Niinobe M,Yoshikawa K,Patti ME,Kahn CR
Exact source Fig. 2S: Down progression
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Source species Mus musculus
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 AFFY_MG_U74
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Version history 3.0: Renamed from IRS_KO_ADIP_DN

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