Human Gene Set: RECHTIEN_PBMC_RVSV_ZEBOV_AGE_18_55YO_1DY_UP

Standard name

RECHTIEN_PBMC_RVSV_ZEBOV_AGE_18_55YO_1DY_UP

Systematic name

M40942

Brief description

Genes up-regulated in peripheral blood mononuclear cell 1d vs 0d in adults (18-55) after exposure to rVSV-ZEBOV , time point 1D

Full description or abstract

Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.

Collection

C7: Immunologic Signature
VAX: HIPC Vaccine Response

Source publication

Pubmed 28854372 Authors: Rechtien A,Richert L,Lorenzo H,Martrus G,Hejblum B,Dahlke C,Kasonta R,Zinser M,Stubbe H,Matschl U,Lohse A,Krähling V,Eickmann M,Becker S,VEBCON Consortium,Thiébaut R,Altfeld M,Addo MM

Exact source

Table 2, NFKB1 and NFKB2 mentioned in text

Related gene sets

(show 20 gene sets from the same authors)