Human Gene Set: MONTERO_THYROID_CANCER_POOR_SURVIVAL_DN


Standard name MONTERO_THYROID_CANCER_POOR_SURVIVAL_DN
Systematic name M6972
Brief description Down-regulated genes predicting poor survival of patients with thyroid carcinoma.
Full description or abstract Undifferentiated and poorly differentiated thyroid tumors are responsible for more than half of thyroid cancer patient deaths in spite of their low incidence. Conventional treatments do not obtain substantial benefits, and the lack of alternative approaches limits patient survival. Additionally, the absence of prognostic markers for well-differentiated tumors complicates patient-specific treatments and favors the progression of recurrent forms. In order to recognize the molecular basis involved in tumor dedifferentiation and identify potential markers for thyroid cancer prognosis prediction, we analysed the expression profile of 44 thyroid primary tumors with different degrees of dedifferentiation and aggressiveness using cDNA microarrays. Transcriptome comparison of dedifferentiated and well-differentiated thyroid tumors identified 1031 genes with >2-fold difference in absolute values and false discovery rate of <0.15. According to known molecular interaction and reaction networks, the products of these genes were mainly clustered in the MAPkinase signaling pathway, the TGF-beta signaling pathway, focal adhesion and cell motility, activation of actin polymerization and cell cycle. An exhaustive search in several databases allowed us to identify various members of the matrix metalloproteinase, melanoma antigen A and collagen gene families within the upregulated gene set. We also identified a prognosis classifier comprising just 30 transcripts with an overall accuracy of 95%. These findings may clarify the molecular mechanisms involved in thyroid tumor dedifferentiation and provide a potential prognosis predictor as well as targets for new therapies.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17873908   Authors: Montero-Conde C,Martín-Campos JM,Lerma E,Gimenez G,Martínez-Guitarte JL,Combalía N,Montaner D,Matías-Guiu X,Dopazo J,de Leiva A,Robledo M,Mauricio D
Exact source Table 3: fold change PPTC/NPPTC < 0
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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