Human Gene Set: MANNE_COVID19_NONICU_VS_HEALTHY_DONOR_PLATELETS_UP


Standard name MANNE_COVID19_NONICU_VS_HEALTHY_DONOR_PLATELETS_UP
Systematic name M38976
Brief description Strongly upregulated genes from differential gene expression analysis of platelets from 6 Non-ICU patients with SARS-CoV-2 infection as well as 5 healthy donors.
Full description or abstract Thrombotic complications in patients with COVID-19 are common and contribute to organ failure and mortality. Patients with severe COVID-19 present with hemostatic abnormalities that mimic disseminated intravascular coagulopathy associated with sepsis with the major difference being increased risk of thrombosis rather than bleeding. However, whether SARS-CoV-2 infection alters platelet function to contribute to the pathophysiology of COVID-19 remains unknown. In this study, we report altered platelet gene expression and functional responses in patients infected with SARS-CoV-2.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32573711   Authors: Manne BK,Denorme F,Middleton EA,Portier I,Rowley JW,Stubben C,Petrey AC,Tolley ND,Guo L,Cody M,Weyrich AS,Yost CC,Rondina MT,Campbell RA
Exact source Supplemental Table 1: Platelet differential gene expression analysis from hospitalized non-ICU COVID-19 patients. Genes with Log2(FC)>2, pAdj<0.05.
Related gene sets (show 5 additional gene sets from the source publication)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 Human_Ensembl_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 143 genes
Gene families ? Categorize these 143 genes by gene family
Show members (show 143 source identifiers mapped to 143 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.