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Human Gene Set: KEGG_MEDICUS_REFERENCE_MEVALONATE_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_MEVALONATE_PATHWAY
Systematic name
M47946
Brief description
Pathway Definition from KEGG: Acetyl-CoA -- ACAT >> HMGCS >> HMGCR >> MVK >> PMVK >> MVD >> IDI >> (FDPS,GGPS1) -> Farnesyl-PP
Full description or abstract
Mevalonate pathway. Pathway ID: N01635. Pathway type: Reference. Pathway class: nt06034 Cholesterol biosynthesis.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01635
Related gene sets
External links
https://www.kegg.jp/entry/N01635
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 12 genes
Gene families
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Show members
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12 source identifiers mapped to 12 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10654
10654
PMVK
phosphomevalonate kinase [Source:HGNC Symbol;A...
2224
2224
FDPS
farnesyl diphosphate synthase [Source:HGNC Sym...
3156
3156
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase [Sour...
3157
3157
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 [Sou...
3158
3158
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 [Sou...
3422
3422
IDI1
isopentenyl-diphosphate delta isomerase 1 [Sou...
38
38
ACAT1
acetyl-CoA acetyltransferase 1 [Source:HGNC Sy...
39
39
ACAT2
acetyl-CoA acetyltransferase 2 [Source:HGNC Sy...
4597
4597
MVD
mevalonate diphosphate decarboxylase [Source:H...
4598
4598
MVK
mevalonate kinase [Source:HGNC Symbol;Acc:HGNC...
91734
91734
IDI2
isopentenyl-diphosphate delta isomerase 2 [Sou...
9453
9453
GGPS1
geranylgeranyl diphosphate synthase 1 [Source:...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-283
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