Human Gene Set: JIANG_MELANOMA_TRM_HIGH_SURVIVAL_22_GENE_SIGNATURE


Standard name JIANG_MELANOMA_TRM_HIGH_SURVIVAL_22_GENE_SIGNATURE
Systematic name M48964
Brief description This gene set comprises a 22-gene signature derived from tissue-resident memory T cells (TRM) specifically associated with improved prognosis in melanoma patients. Enrichment of this signature in the tumor immune microenvironment (TIME) correlates with heightened immune activation, particularly involving T cells, NK cells, and M1 macrophages. High TRM infiltration is linked with longer overall survival and a more robust immune response. This signature enables stratification of melanoma patients into low- and high-risk categories, providing significant prognostic insights and aiding in the prediction of patient outcomes.
Full description or abstract Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated. Here, we systematically investigated the relationship between TRM and melanoma TIME based on multiple clinical single-cell RNA-seq datasets and developed signatures indicative of TRM infiltration. TRM infiltration is associated with longer overall survival and abundance of T cells, NK cells, M1 macrophages, and memory B cells in the TIME. A 22-gene TRM derived risk score was further developed to effectively classify patients into low- and high-risk categories, distinguishing overall survival and immune activation, particularly in T cell-mediated responses. Altogether, our analysis suggests that TRM abundance is associated with melanoma TIME activation and patient survival, and the TRM-based machine learning model can potentially predict prognosis in melanoma patients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38455971   Authors: Jiang C,Chao CC,Li J,Ge X,Shen A,Jucaud V,Cheng C,Shen X
Exact source Supplemental Table 3. The Beta_i values for all the 22 genes. Related to Figure 5.
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External links https://www.cell.com/iscience/fulltext/S2589-0042(24)00498-X
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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