Human Gene Set: JIANG_MELANOMA_TRM1_CD8


Standard name JIANG_MELANOMA_TRM1_CD8
Systematic name M48965
Brief description  
Full description or abstract Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated. Here, we systematically investigated the relationship between TRM and melanoma TIME based on multiple clinical single-cell RNA-seq datasets and developed signatures indicative of TRM infiltration. TRM infiltration is associated with longer overall survival and abundance of T cells, NK cells, M1 macrophages, and memory B cells in the TIME. A 22-gene TRM derived risk score was further developed to effectively classify patients into low- and high-risk categories, distinguishing overall survival and immune activation, particularly in T cell-mediated responses. Altogether, our analysis suggests that TRM abundance is associated with melanoma TIME activation and patient survival, and the TRM-based machine learning model can potentially predict prognosis in melanoma patients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38455971   Authors: Jiang C,Chao CC,Li J,Ge X,Shen A,Jucaud V,Cheng C,Shen X
Exact source Supplemental Table 1. Tissue resident memory T cells cluster-specific maker gene sets. Related to Figure 2.
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External links https://www.cell.com/iscience/fulltext/S2589-0042(24)00498-X
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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