Human Gene Set: FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_DN


Standard name FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_DN
Systematic name M761
Brief description Genes down-regulated in basal radial glia (bRG) relative to apical radial glia (aRG), and up-regulated in both aRG and bRG relative to neurons.
Full description or abstract Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 25721503   Authors: Florio M,Albert M,Taverna E,Namba T,Brandl H,Lewitus E,Haffner C,Sykes A,Wong FK,Peters J,Guhr E,Klemroth S,Prüfer K,Kelso J,Naumann R,Nüsslein I,Dahl A,Lachmann R,Pääbo S,Huttner WB
Exact source Table 1S: aRG>bRG>N (190)
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 Human_Ensembl_Gene_ID
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Version history 6.2: First introduced

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