Standard name |
CURSONS_NATURAL_KILLER_CELLS |
Systematic name |
M45040 |
Brief description |
Genes up-regulated in natural killer cells. |
Full description or abstract |
A preliminary gene set was obtained by combining the CIBERSORT (LM22) and Tosolini et al (LM7) gene sets for natural killer (NK) cells, together with a selection of marker genes from mouse NK cell studies (Huntington gene lists). Genes were filtered using by using bulk RNA-seq (GSE60424; via differential expression between NK cells and other sorted blood cell populations) and single cell RNA-seq (GSE72056; comparing various percentile thresholds between immune cell subsets) to select genes with particularly high transcript abundance within NK cells. The resulting gene set was further filtered to remove any genes which also show moderate-high expression within solid tumor cell lines from the Cancer Cell Line Encyclopedia. Genes filtered at various steps are labelled in Table S1 from the original publication (see EXTERNAL_DETAILS_URL). For a graphical summary please refer to Supplementary Figure S2 from DOI: 10.1158/2326-6066.CIR-18-0500 |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 31088844 Authors: Cursons J,Souza-Fonseca-Guimaraes F,Foroutan M,Anderson A,Hollande F,Hediyeh-Zadeh S,Behren A,Huntington ND,Davis MJ |
Exact source |
Supplementary Table 1 - Official gene symbols (HGNC) for our 20 NK signature genes and a subset of the results leading to their inclusion during curation, in particular bulk RNA-seq differential expression results and comparison to T cells for single-cell RNA-seq data from Tirosh et al (2016). For further details please refer to the Materials and Methods. LM22: CIBERSORT LM22 lists; LM7: Tosolini et al LM7 list. |
Related gene sets |
(show 6 gene sets from the same authors)
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External links |
https://cancerimmunolres.aacrjournals.org/highwire/filestream/37099/field_highwire_adju...
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Dharmesh D. Bhuva (Walter and Eliza Hall Institute of Medical Research) |
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
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Compendia expression profiles ? |
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 20 genes
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Gene families ? |
Categorize these
20 genes by gene family
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Show members |
(show 20 source identifiers mapped to 20 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
CD160 |
11126 |
CD160 |
CD160 molecule [Source:HGNC Symbol;Acc:HGNC... |
CD244 |
51744 |
CD244 |
CD244 molecule [Source:HGNC Symbol;Acc:HGNC... |
CTSW |
1521 |
CTSW |
cathepsin W [Source:HGNC Symbol;Acc:HGNC:2546] |
FASLG |
356 |
FASLG |
Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] |
GZMA |
3001 |
GZMA |
granzyme A [Source:HGNC Symbol;Acc:HGNC:4708] |
GZMB |
3002 |
GZMB |
granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] |
GZMH |
2999 |
GZMH |
granzyme H [Source:HGNC Symbol;Acc:HGNC:4710] |
IL18RAP |
8807 |
IL18RAP |
interleukin 18 receptor accessory protein [... |
IL2RB |
3560 |
IL2RB |
interleukin 2 receptor subunit beta [Source... |
KIR2DL4 |
3805 |
KIR2DL4 |
killer cell immunoglobulin like receptor, t... |
KLRB1 |
3820 |
KLRB1 |
killer cell lectin like receptor B1 [Source... |
KLRC3 |
3823 |
KLRC3 |
killer cell lectin like receptor C3 [Source... |
KLRD1 |
3824 |
KLRD1 |
killer cell lectin like receptor D1 [Source... |
KLRF1 |
51348 |
KLRF1 |
killer cell lectin like receptor F1 [Source... |
KLRK1 |
22914 |
KLRK1 |
killer cell lectin like receptor K1 [Source... |
NCR1 |
9437 |
NCR1 |
natural cytotoxicity triggering receptor 1 ... |
NKG7 |
4818 |
NKG7 |
natural killer cell granule protein 7 [Sour... |
PRF1 |
5551 |
PRF1 |
perforin 1 [Source:HGNC Symbol;Acc:HGNC:9360] |
XCL1 |
6375 |
XCL1 |
X-C motif chemokine ligand 1 [Source:HGNC S... |
XCL2 |
6846 |
XCL2 |
X-C motif chemokine ligand 2 [Source:HGNC S... |
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Version history |
2022.1.Hs: First Introduced.
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